human dna sequence 12 contains more than 1,400 coding genes1 and 487 loci that are directly involved in human disease2. The q arm of human dna sequence 12 contains one of the largest blocks of linkage disequilibrium in human genome3. Here we present the finished sequence of human chromosome 12, the high quality and spans approximately 132 megabases, which is completed approx4.5% of the human genome. Orientation of human chromosome 12 sequence in vertebratereveals the origin of individual segments of chicken and a unique history of rearrangement through lines of rodents and primates. The exchange rate of the recent evolutionary history shows an overall slowing in hominids compared with primates and rodents.
Among the projects of human dna sequence, chromosome 12 sequencing effort benefited most from a previous sequence has advanced site (STS) physical map, the 5300 and 3100 large insert clones containing a markeraverage resolution of 44 kilobases (kb) 4 Insert after integration with the entire genome map5 fingerprints, a tiling path of clones in the 1168 final great choice for shotgun sequencing of clone-by-clone sequencing strategy. Each clone was the rules of the community (http://www.genome.gov/10001812) producing 130 683 379 base pairs (bp) sequence overlap independently measured as more than 99.99% accurate6 ready. The characteristics and observations presented here can be regarded asUser specified title in the genome browser Genboree (http://www.genboree.org/Hs.chr12).
